Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol

The activation mechanism of the classical transient receptor potential channels TRPC4 and -5 via the G(q/11) protein-phospholipase C (PLC) signaling pathway has remained elusive so far. In contrast to all other TRPC channels, the PLC product diacylglycerol (DAG) is not sufficient for channel activat...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Storch, Ursula, Forst, Anna-Lena, Pardatscher, Franziska, Erdogmus, Serap, Philipp, Maximilian, Gregoritza, Manuel, Mederos y Schnitzler, Michael, Gudermann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224389/
https://ncbi.nlm.nih.gov/pubmed/27994151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612263114
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