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Dynamic NHERF interaction with TRPC4/5 proteins is required for channel gating by diacylglycerol
The activation mechanism of the classical transient receptor potential channels TRPC4 and -5 via the G(q/11) protein-phospholipase C (PLC) signaling pathway has remained elusive so far. In contrast to all other TRPC channels, the PLC product diacylglycerol (DAG) is not sufficient for channel activat...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2017
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5224389/ https://ncbi.nlm.nih.gov/pubmed/27994151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612263114 |
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