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p97 Disease Mutations Modulate Nucleotide-Induced Conformation to Alter Protein–Protein Interactions
[Image: see text] The AAA+ ATPase p97/VCP adopts at least three conformations that depend on the binding of ADP and ATP and alter the orientation of the N-terminal protein–protein interaction (PPI) domain into “up” and “down” conformations. Point mutations that cause multisystem proteinopathy 1 (MSP...
Tallennettuna:
| Julkaisussa: | ACS Chem Biol |
|---|---|
| Päätekijät: | , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Chemical
Society
2016
|
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5224236/ https://ncbi.nlm.nih.gov/pubmed/27267671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00350 |
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