Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats

Opiate analgesia in the spinal cord is impaired in diabetic neuropathic pain (DNP), but until now the reason is unknown. We hypothesized that it resulted from a decreased inhibition of substance P (SP) signaling within the dorsal horn of the spinal cord. To investigate this possibility, we evaluated...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Wan, Fa-Ping, Bai, Yang, Kou, Zhen-Zhen, Zhang, Ting, Li, Hui, Wang, Ya-Yun, Li, Yun-Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223733/
https://ncbi.nlm.nih.gov/pubmed/28119567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2016.00167
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