Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2

The critical initiation phase of clathrin-mediated endocytosis (CME) determines where and when endocytosis occurs. Heterotetrameric adaptor protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by conformational changes in response to phosphatidylinositol-4,5-bi...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Kadlecova, Zuzana, Spielman, Stephanie J., Loerke, Dinah, Mohanakrishnan, Aparna, Reed, Dana Kim, Schmid, Sandra L.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223608/
https://ncbi.nlm.nih.gov/pubmed/28003333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201608071
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