Dynamin-Related Protein 1 Deficiency Leads to Receptor-Interacting Protein Kinase 3–Mediated Necroptotic Neurodegeneration

Mitochondria are dynamic organelles that divide and fuse to modulate their number and shape. We have previously reported that the loss of dynamin-related protein 1 (Drp1), which mediates mitochondrial division, leads to the degeneration of cerebellar Purkinje cells in mice. Because Drp1 has been sho...

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Bibliographic Details
Published in:Am J Pathol
Main Authors: Yamada, Tatsuya, Adachi, Yoshihiro, Fukaya, Masahiro, Iijima, Miho, Sesaki, Hiromi
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2016
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222987/
https://ncbi.nlm.nih.gov/pubmed/27640145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.06.025
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