SAG/Rbx2-Dependent Neddylation Regulates T-Cell Responses

Neddylation is a crucial post-translational modification that depends on the E3 cullin ring ligase (CRL). The E2-adapter component of the CRL, sensitive to apoptosis gene (SAG), is critical for the function of CRL-mediated ubiquitination; thus, the deletion of SAG regulates neddylation. We examined...

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Vydáno v:Am J Pathol
Hlavní autoři: Mathewson, Nathan D., Fujiwara, Hideaki, Wu, Shin-Rong, Toubai, Tomomi, Oravecz-Wilson, Katherine, Sun, Yaping, Rossi, Corinne, Zajac, Cynthia, Sun, Yi, Reddy, Pavan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2016
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222982/
https://ncbi.nlm.nih.gov/pubmed/27543965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.06.014
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