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Fractalkine Signaling Attenuates Perivascular Clustering of Microglia and Fibrinogen Leakage during Systemic Inflammation in Mouse Models of Diabetic Retinopathy

Fractalkine (FKN) is a chemokine expressed constitutively by healthy neurons and signals to microglia upon interaction with the FKN receptor, CX3CR1. Signaling between FKN and CX3CR1 transduces inhibitory signals that ameliorate microglial activation and proinflammatory cytokine release in neuroinfl...

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Detalhes bibliográficos
Publicado no:Front Cell Neurosci
Main Authors: Mendiola, Andrew S., Garza, Rolando, Cardona, Sandra M., Mythen, Shannon A., Lira, Sergio A., Akassoglou, Katerina, Cardona, Astrid E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222852/
https://ncbi.nlm.nih.gov/pubmed/28119571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2016.00303
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