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Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection

The sarcomeric cytoskeleton is a network of modular proteins that integrate mechanical and signaling roles. Obscurin, or its homolog obscurin-like-1, bridges the giant ruler titin and the myosin crosslinker myomesin at the M-band. Yet, the molecular mechanisms underlying the physical obscurin(-like-...

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Publicat a:Structure
Autors principals: Pernigo, Stefano, Fukuzawa, Atsushi, Beedle, Amy E.M., Holt, Mark, Round, Adam, Pandini, Alessandro, Garcia-Manyes, Sergi, Gautel, Mathias, Steiner, Roberto A.
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222588/
https://ncbi.nlm.nih.gov/pubmed/27989621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.11.015
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