Both BC-Box Motifs of Adenovirus Protein E4orf6 Are Required To Efficiently Assemble an E3 Ligase Complex That Degrades p53

Small DNA tumor viruses typically encode proteins that either inactivate or degrade p53. Human adenoviruses encode products, including E4orf6 and E1B55K, that do both. Each independently binds to p53 and inhibits its ability to activate gene expression; however, in combination they induce p53 degrad...

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Библиографические подробности
Главные авторы: Blanchette, Paola, Cheng, Chi Ying, Yan, Qin, Ketner, Gary, Ornelles, David A., Dobner, Thomas, Conaway, Ronald C., Conaway, Joan Weliky, Branton, Philip E.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2004
Предметы:
Gene Expression
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC522240/
https://ncbi.nlm.nih.gov/pubmed/15485928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9619-9629.2004
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