Notch Subunit Heterodimerization and Prevention of Ligand-Independent Proteolytic Activation Depend, Respectively, on a Novel Domain and the LNR Repeats

Notch proteins are transmembrane receptors that participate in a highly conserved signaling pathway that regulates morphogenesis in metazoans. Newly synthesized Notch receptors are proteolytically cleaved during transit to the cell surface, creating heterodimeric mature receptors comprising noncoval...

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Главные авторы: Sanchez-Irizarry, Cheryll, Carpenter, Andrea C., Weng, Andrew P., Pear, Warren S., Aster, Jon C., Blacklow, Stephen C.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2004
Предметы:
Cell Growth and Development
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC522238/
https://ncbi.nlm.nih.gov/pubmed/15485896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9265-9273.2004
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