Serine Phosphorylation Proximal to Its Phosphotyrosine Binding Domain Inhibits Insulin Receptor Substrate 1 Function and Promotes Insulin Resistance

Ser/Thr phosphorylation of insulin receptor substrate (IRS) proteins negatively modulates insulin signaling. Therefore, the identification of serine sites whose phosphorylation inhibit IRS protein functions is of physiological importance. Here we mutated seven Ser sites located proximal to the phosp...

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Detalhes bibliográficos
Main Authors: Liu, Yan-Fang, Herschkovitz, Avia, Boura-Halfon, Sigalit, Ronen, Denise, Paz, Keren, LeRoith, Derek, Zick, Yehiel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522236/
https://ncbi.nlm.nih.gov/pubmed/15485932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9668-9681.2004
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