Uterus Hyperplasia and Increased Carcinogen-Induced Tumorigenesis in Mice Carrying a Targeted Mutation of the Chk2 Phosphorylation Site in Brca1

The tumor suppressor BRCA1 contains multiple functional domains that interact with many proteins. After DNA damage, BRCA1 is phosphorylated by CHK2 at serine 988, followed by a change in its intracellular location. To study the functions of CHK2-dependent phosphorylation of BRCA1, we generated a mou...

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Bibliografiske detaljer
Main Authors: Kim, Sang Soo, Cao, Liu, Li, Cuiling, Xu, Xiaoling, Huber, L. Julie, Chodosh, Lewis A., Deng, Chu-Xia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC522227/
https://ncbi.nlm.nih.gov/pubmed/15485917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.21.9498-9507.2004
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