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Chk2 Activation and Phosphorylation-Dependent Oligomerization
The tumor suppressor gene CHK2 encodes a versatile effector serine/threonine kinase involved in responses to DNA damage. Chk2 has an amino-terminal SQ/TQ cluster domain (SCD), followed by a forkhead-associated (FHA) domain and a carboxyl-terminal kinase catalytic domain. Mutations in the SCD or FHA...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133858/ https://ncbi.nlm.nih.gov/pubmed/12024051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.22.12.4419-4432.2002 |
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