Loss of the HVEM tumor suppressor in lymphoma and restoration by modified CAR-T cells

The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM deficient lymphoma B cells also induce a tumor s...

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Publicado no:Cell
Main Authors: Boice, Michael, Salloum, Darin, Mourcin, Frederic, Sanghvi, Viraj, Amin, Rada, Oricchio, Elisa, Jiang, Man, Mottok, Anja, Denis-Lagache, Nicolas, Ciriello, Giovanni, Tam, Wayne, Teruya-Feldstein, Julie, de Stanchina, Elisa, Chan, Wing C., Malek, Sami N., Ennishi, Daisuke, Brentjens, Renier J., Gascoyne, Randy D., Cogne, Michel, Tarte, Karin, Wendel, Hans-Guido
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221752/
https://ncbi.nlm.nih.gov/pubmed/27693350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.08.032
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