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Extending the dynamic range of transcription factor action by translational regulation

A crucial step in the regulation of gene expression is binding of transcription factor (TF) proteins to regulatory sites along the DNA. But transcription factors act at nanomolar concentrations, and noise due to random arrival of these molecules at their binding sites can severely limit the precisio...

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Bibliografiske detaljer
Udgivet i:Phys Rev E
Main Authors: Sokolowski, Thomas R., Walczak, Aleksandra M., Bialek, William, Tkačik, Gašper
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221721/
https://ncbi.nlm.nih.gov/pubmed/26986359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1103/PhysRevE.93.022404
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