Physiologically relevant binding affinity quantification of monoclonal antibody PF‐00547659 to mucosal addressin cell adhesion molecule for in vitro in vivo correlation

BACKGROUND AND PURPOSE: A monoclonal antibody (PF‐00547659) against mucosal addressin cell adhesion molecule (MAdCAM), expressed as both soluble (sMAdCAM) and trans‐membrane (mMAdCAM) target forms, showed over 30‐fold difference in antibody‐target K(D) between in vitro (Biacore) and clinically deriv...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Wang, Mengmeng, Kussrow, Amanda K, Ocana, Mireia Fernandez, Chabot, Jeffrey R, Lepsy, Christopher S, Bornhop, Darryl J, O'Hara, Denise M
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2016
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Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5221447/
https://ncbi.nlm.nih.gov/pubmed/27760281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13654
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