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Family Shuffling of Expandase Genes To Enhance Substrate Specificity for Penicillin G
Deacetoxycephalosporin C synthase (expandase) from Streptomyces clavuligerus, encoded by cefE, is an important industrial enzyme for the production of 7-aminodeacetoxycephalosporanic acid from penicillin G. To improve the substrate specificity for penicillin G, eight cefE-homologous genes were direc...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology
2004
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522083/ https://ncbi.nlm.nih.gov/pubmed/15466573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.70.10.6257-6263.2004 |
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