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Engineering the Substrate Specificity of a Thermophilic Penicillin Acylase from Thermus thermophilus
A homologue of the Escherichia coli penicillin acylase is encoded in the genomes of several thermophiles, including in different Thermus thermophilus strains. Although the natural substrate of this enzyme is not known, this acylase shows a marked preference for penicillin K over penicillin G. Three-...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3591942/ https://ncbi.nlm.nih.gov/pubmed/23263966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03215-12 |
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