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Engineering the Substrate Specificity of a Thermophilic Penicillin Acylase from Thermus thermophilus

A homologue of the Escherichia coli penicillin acylase is encoded in the genomes of several thermophiles, including in different Thermus thermophilus strains. Although the natural substrate of this enzyme is not known, this acylase shows a marked preference for penicillin K over penicillin G. Three-...

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Bibliografski detalji
Glavni autori: Torres, Leticia L., Cantero, Ángel, del Valle, Mercedes, Marina, Anabel, López-Gallego, Fernando, Guisán, José M., Berenguer, José, Hidalgo, Aurelio
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591942/
https://ncbi.nlm.nih.gov/pubmed/23263966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03215-12
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