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Novel approaches to mitigating parathion toxicity: targeting cytochrome P450–mediated metabolism with menadione
Accidental or intentional exposures to parathion, an organophosphorus (OP) pesticide, can cause severe poisoning in humans. Parathion toxicity is dependent on its metabolism by the cytochrome P450 (CYP) system to paraoxon (diethyl 4-nitrophenyl phosphate), a highly poisonous nerve agent and potent i...
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| Publicado no: | Ann N Y Acad Sci |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5220671/ https://ncbi.nlm.nih.gov/pubmed/27441453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.13156 |
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