A Single Amino Acid Substitution Converts γ-Glutamyltranspeptidase to a Class IV Cephalosporin Acylase (Glutaryl-7-Aminocephalosporanic Acid Acylase)

The aspartyl residue at position 433 of γ-glutamyltranspeptidase of Escherichia coli K-12 was replaced by an asparaginyl residue. This substitution enabled γ-glutamyltranspeptidase to deacylate glutaryl-7-aminocephalosporanic acid, producing 7-aminocephalosporanic acid, which is a starting material...

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Detalhes bibliográficos
Main Authors: Suzuki, Hideyuki, Miwa, Chinatsu, Ishihara, Sayaka, Kumagai, Hidehiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Physiology and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC522061/
https://ncbi.nlm.nih.gov/pubmed/15466585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.70.10.6324-6328.2004
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