Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin

Inhibition of the potassium channels TREK-1 by spadin (SPA) is currently thought to be a promising therapeutic target for the treatment of depression. Since these channels are expressed in pancreatic β-cells, we investigated their role in the control of insulin secretion and glucose homeostasis. In...

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Vydáno v:J Diabetes Res
Hlavní autoři: Hivelin, Céline, Béraud-Dufour, Sophie, Devader, Christelle, Abderrahmani, Amar, Moreno, Sébastien, Moha ou Maati, Hamid, Djillani, Alaeddine, Heurteaux, Catherine, Borsotto, Marc, Mazella, Jean, Coppola, Thierry
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220496/
https://ncbi.nlm.nih.gov/pubmed/28105440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/3142175
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