In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin

BACKGROUND AND PURPOSE: We have described a novel antidepressant peptide, spadin, that acts by blocking the TWIK-related-potassium channel, type 1 (TREK-1). Here, we examined possible mechanisms of action of spadin at both molecular and cellular levels. EXPERIMENTAL APPROACHES: Effects of spadin wer...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Devader, C, Khayachi, A, Veyssière, J, Moha ou Maati, H, Roulot, M, Moreno, S, Borsotto, M, Martin, S, Heurteaux, C, Mazella, J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4409910/
https://ncbi.nlm.nih.gov/pubmed/25598009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13083
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