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A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen

A unique characteristic of the hepatitis B virus is the production of a secreted form (precore or HBeAg) of the structural nucleocapsid (core or HBcAg). By using T cell receptor (TCR) transgenic (Tg) and TCR × HBc/HBeAg double- and triple-Tg pairs, we demonstrate that HBeAg elicits T cell tolerance,...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Chen, Margaret T., Billaud, Jean-Noel, Sällberg, Matti, Guidotti, Luca G., Chisari, Francis V., Jones, Joyce, Hughes, Janice, Milich, David R.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522042/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15469922/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0406282101
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