Effect of A-769662, a direct AMPK activator, on Tlr-4 expression and activity in mice heart tissue

OBJECTIVE(S):: TLR-4 activates a number of inflammatory signaling pathways. Also, AMPK could be involved in anti-inflammatory signaling. The aim of this study was to identify whether stimulation of AMPK could inhibit LPS-induced Tlr-4 gene expression in mice hearts. MATERIALS AND METHODS: Heart AMPK...

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Опубликовано в: :Iran J Basic Med Sci
Главные авторы: Rameshrad, Maryam, Maleki-Dizaji, Nasrin, Soraya, Hamid, Toutounchi, Negisa Seyed, Barzegari, Abolfazl, Garjani, Alireza
Формат: Artigo
Язык:Inglês
Опубликовано: Mashhad University of Medical Sciences 2016
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220236/
https://ncbi.nlm.nih.gov/pubmed/28096963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22038/ijbms.2016.7917
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