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Exact confidence limits for the response rate in two-stage designs with over- or under-enrollment in the second stage
Simon’s two-stage design has been widely used in early phase clinical trials to assess the activity of a new investigated treatment. In practice, the actual sample sizes do not always follow the study design precisely, especially in the second stage. When over- or under-enrollment occurs in a study,...
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| 出版年: | Stat Methods Med Res |
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| 第一著者: | |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5219879/ https://ncbi.nlm.nih.gov/pubmed/27389669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0962280216650918 |
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