Cryptotanshinone activates AMPK-TSC2 axis leading to inhibition of mTORC1 signaling in cancer cells

BACKGROUND: Cryptotanshinone (CPT), a fat-soluble phenanthraquinone from Salvia miltiorrhiza Bunge, has been demonstrated to inhibit phosphorylation of p70 S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E binding protein 1 (4E-BP1), a couple of direct downstream effectors of the mammalian targ...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Chen, Wenxing, Pan, Yanhong, Wang, Siliang, Liu, Yuping, Chen, Guangying, Zhou, Liang, Ni, Wenting, Wang, Aiyun, Lu, Yin
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5219700/
https://ncbi.nlm.nih.gov/pubmed/28061838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-3038-y
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