In Vitro Activities of 2,4-Diaminoquinazoline and 2,4-Diaminopteridine Derivatives against Plasmodium falciparum

The activities of 28 6-substituted 2,4-diaminoquinazolines, 2,4-diamino-5,6,7,8-tetrahydroquinazolines, and 2,4-diaminopteridines against Plasmodium falciparum were tested. The 50% inhibitory concentrations (IC(50)s) of six compounds were <50 nM, and the most potent compound was 2,4-diamino-5-chl...

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Main Authors: Ommeh, Sheila, Nduati, Eunice, Mberu, Eddy, Kokwaro, Gilbert, Marsh, Kevin, Rosowsky, Andre, Nzila, Alexis
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Susceptibility
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC521929/
https://ncbi.nlm.nih.gov/pubmed/15388424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.10.3711-3714.2004
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