Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis

Proteolysis of autoantigens can alter normal MHC class II antigen processing and has been implicated in the induction of autoimmune diseases. Many autoantigens are substrates for the protease granzyme B (GrB), but the mechanistic significance of this association is unknown. Peptidylarginine deiminas...

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Foilsithe in:J Proteome Res
Main Authors: Darrah, Erika, Kim, AeRyon, Zhang, Xi, Boronina, Tatiana, Cole, Robert N., Fava, Andrea, Giles, Jon T., Bingham, Clifton O., Chalmers, Michael J., Griffin, Patrick R., Sadegh-Nasseri, Scheherazade, Rosen, Antony
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5218978/
https://ncbi.nlm.nih.gov/pubmed/27700100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.6b00617
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