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Structure-Based Understanding of Binding Affinity and Mode of Estrogen Receptor α Agonists and Antagonists
The flexible hydrophobic ligand binding pocket (LBP) of estrogen receptor α (ERα) allows the binding of a wide variety of endocrine disruptors. Upon ligand binding, the LBP reshapes around the contours of the ligand and stabilizes the complex by complementary hydrophobic interactions and specific hy...
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| Gepubliceerd in: | PLoS One |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5218732/ https://ncbi.nlm.nih.gov/pubmed/28061508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169607 |
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