Thogoto Virus Lacking Interferon-Antagonistic Protein ML Is Strongly Attenuated in Newborn Mx1-Positive but Not Mx1-Negative Mice

The Thogoto virus ML protein suppresses interferon synthesis in infected cells. Nevertheless, a virus mutant lacking ML remained highly pathogenic in standard laboratory mice. It was strongly attenuated, however, in mice carrying the interferon-responsive Mx1 gene found in wild mice, demonstrating t...

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Bibliographic Details
Main Authors: Pichlmair, Andreas, Buse, Johanna, Jennings, Stephanie, Haller, Otto, Kochs, Georg, Staeheli, Peter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC521850/
https://ncbi.nlm.nih.gov/pubmed/15452266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.20.11422-11424.2004
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