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Human Cytomegalovirus Infection Induces Rapamycin-Insensitive Phosphorylation of Downstream Effectors of mTOR Kinase

Signaling mediated by the cellular kinase mammalian target of rapamycin (mTOR) activates cap-dependent translation under normal (nonstressed) conditions. However, translation is inhibited by cellular stress responses or rapamycin treatment, which inhibit mTOR kinase activity. We show that during hum...

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Autors principals: Kudchodkar, Sagar B., Yu, Yongjun, Maguire, Tobi G., Alwine, James C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521827/
https://ncbi.nlm.nih.gov/pubmed/15452223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.20.11030-11039.2004
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