Phase I study of irinotecan for previously treated lung cancer patients with the UGT1A1 * 28 or * 6 polymorphism: Results of the Lung Oncology Group in Kyushu (LOGIK1004A)

BACKGROUND: Various polymorphisms have been detected in the UDP‐glucuronosyltransferase 1A (UGT1A) gene, and UGT1A1 *28 and UGT1A1 *6 have important effects on the pharmacokinetics of irinotecan and the risk of severe toxicities during irinotecan therapy. This study was conducted to determine the ma...

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Veröffentlicht in:Thorac Cancer
Hauptverfasser: Fukuda, Minoru, Shimada, Midori, Kitazaki, Takeshi, Nagashima, Seiji, Hashiguchi, Kohji, Ebi, Noriyuki, Takayama, Koichi, Nakanishi, Yoichi, Semba, Hiroshi, Harada, Taishi, Seto, Takashi, Okamoto, Isamu, Ichinose, Yukito, Sugio, Kenji
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons Australia, Ltd 2016
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217920/
https://ncbi.nlm.nih.gov/pubmed/27883280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1759-7714.12407
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