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Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: implications for optimizing preclinical neuroscience drug discovery

Allosteric modulators, that exhibit no intrinsic agonist activity, offer the advantage of spatial and temporal fine-tuning of endogenous agonist activity, allowing the potential for increased selectivity, reduced adverse effects and improved clinical outcomes. Some allosteric ligands can differentia...

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Dettagli Bibliografici
Pubblicato in:Neuropharmacology
Autori principali: Sengmany, Kathy, Singh, Junaid, Stewart, Gregory D., Conn, P. Jeffrey, Christopoulos, Arthur, Gregory, Karen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217481/
https://ncbi.nlm.nih.gov/pubmed/27392634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2016.07.001
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