Activity-Based Proteomics Reveals Heterogeneous Kinome and ATP-Binding Proteome Responses to MEK Inhibition in KRAS Mutant Lung Cancer

One way cancer cells can escape from targeted agents is through their ability to evade drug effects by rapidly rewiring signaling networks. Many protein classes, such as kinases and metabolic enzymes, are regulated by ATP binding and hydrolysis. We hypothesized that a system-level profiling of drug-...

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Pubblicato in:Proteomes
Autori principali: Kim, Jae-Young, Stewart, Paul A., Borne, Adam L., Fang, Bin, Welsh, Eric A., Chen, Yian Ann, Eschrich, Steven A., Koomen, John M., Haura, Eric B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217344/
https://ncbi.nlm.nih.gov/pubmed/28154798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/proteomes4020016
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