Activity-Based Proteomics Reveals Heterogeneous Kinome and ATP-Binding Proteome Responses to MEK Inhibition in KRAS Mutant Lung Cancer

One way cancer cells can escape from targeted agents is through their ability to evade drug effects by rapidly rewiring signaling networks. Many protein classes, such as kinases and metabolic enzymes, are regulated by ATP binding and hydrolysis. We hypothesized that a system-level profiling of drug-...

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Detaylı Bibliyografya
Yayımlandı:Proteomes
Asıl Yazarlar: Kim, Jae-Young, Stewart, Paul A., Borne, Adam L., Fang, Bin, Welsh, Eric A., Chen, Yian Ann, Eschrich, Steven A., Koomen, John M., Haura, Eric B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217344/
https://ncbi.nlm.nih.gov/pubmed/28154798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/proteomes4020016
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