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Driving Structure-Based Drug Discovery through Cosolvent Molecular Dynamics

Identifying binding hotspots on protein surfaces is of prime interest in structure-based drug discovery, either to assess the tractability of pursuing a protein target or to drive improved potency of lead compounds. Computational approaches to detect such regions have traditionally relied on energy...

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Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Ghanakota, Phani, Carlson, Heather A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217181/
https://ncbi.nlm.nih.gov/pubmed/27486927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00399
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