Progressive Cl(−) channel defects reveal disrupted skeletal muscle maturation in R6/2 Huntington’s mice

Huntington’s disease (HD) patients suffer from progressive and debilitating motor dysfunction. Previously, we discovered reduced skeletal muscle chloride channel (ClC-1) currents, inwardly rectifying potassium (Kir) channel currents, and membrane capacitance in R6/2 transgenic HD mice. The ClC-1 los...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Gen Physiol
Auteurs principaux: Miranda, Daniel R., Wong, Monica, Romer, Shannon H., McKee, Cynthia, Garza-Vasquez, Gabriela, Medina, Alyssa C., Bahn, Volker, Steele, Andrew D., Talmadge, Robert J., Voss, Andrew A.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217084/
https://ncbi.nlm.nih.gov/pubmed/27899419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611603
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