Enhanced cytotoxicity of reovirus and radiotherapy in melanoma cells is mediated through increased viral replication and mitochondrial apoptotic signalling

Oncolytic viruses selectively target and replicate in cancer cells, providing us with a unique tool with which to target and kill tumour cells. These viruses come from a diverse range of viral families including reovirus type 3 Dearing (RT3D), a non-pathogenic human double-stranded RNA oncolytic vir...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: McEntee, Gráinne, Kyula, Joan N., Mansfield, David, Smith, Henry, Wilkinson, Michelle, Gregory, Claire, Roulstone, Victoria, Coffey, Matt, Harrington, Kevin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217035/
https://ncbi.nlm.nih.gov/pubmed/27384486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10365
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