Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancerassociated fibroblast accumulation

We previously demonstrated that cancer-associated fibroblasts (CAFs) accumulate at tumor sites through the interaction between a chemokine, CCL3, and its receptor, CCR5, in the late phase of colitis-associated colon carcinogenesis. Here we examined the effect of a CCR5 antagonist, maraviroc, on tumo...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Tanabe, Yamato, Sasaki, Soichiro, Mukaida, Naofumi, Baba, Tomohisa
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217021/
https://ncbi.nlm.nih.gov/pubmed/27340784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10227
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