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BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells
mTOR activation is commonly caused by oncogenic mutations in RAS/RAF/MAPK and PI3K/AKT pathways, and promotes cancer progression and therapeutic resistance. However, mTOR inhibitors show limited single agent efficacy in patients. mTOR inhibitors suppress tumor cell growth and angiogenesis, and have...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5216972/ https://ncbi.nlm.nih.gov/pubmed/27351224 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10277 |
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