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Augmentation of response to nab-paclitaxel by inhibition of insulin-like growth factor (IGF) signaling in preclinical pancreatic cancer models

Nab-paclitaxel has recently shown greater efficacy in pancreatic ductal adenocarcinoma (PDAC). Insulin like growth factor (IGF) signaling proteins are frequently overexpressed in PDAC and correlate with aggressive tumor phenotype and poor prognosis. We evaluated the improvement in nab-paclitaxel res...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Awasthi, Niranjan, Scire, Emily, Monahan, Sheena, Grojean, Meghan, Zhang, Eric, Schwarz, Margaret A., Schwarz, Roderich E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216918/
https://ncbi.nlm.nih.gov/pubmed/27127884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9029
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