The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus

Humanin is a small secreted peptide that is encoded in the mitochondrial genome. Humanin and its analogues have a protective role in multiple age-related diseases including type 2 diabetes and Alzheimer's disease, through cytoprotective and neuroprotective effects both in vitro and in vivo. How...

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Vydáno v:Oncotarget
Hlavní autoři: Kim, Su-Jeong, Guerrero, Noel, Wassef, Gabriella, Xiao, Jialin, Mehta, Hemal H., Cohen, Pinchas, Yen, Kelvin
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper: Gerotarget (Focus on Aging)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216912/
https://ncbi.nlm.nih.gov/pubmed/27384491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10380
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