Caveolin-1 regulates hormone resistance through lipid synthesis, creating novel therapeutic opportunities for castration-resistant prostate cancer

Caveolin-1 (Cav-1) is overexpressed in aggressive and metastatic prostate cancer (PCa) and induces PCa cell proliferation. Androgens mediate lipid synthesis through acetyl-CoA carboxylase-1 (ACC1) and fatty acid synthase (FASN). We investigated the Cav-1-mediated lipid synthesis in the development o...

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Vydáno v:Oncotarget
Hlavní autoři: Karantanos, Theodoros, Karanika, Styliani, Wang, Jianxiang, Yang, Guang, Dobashi, Masato, Park, Sanghee, Ren, Chengzhen, Li, Likun, Basourakos, Spyridon P., Hoang, Anh, Efstathiou, Eleni, Wang, Xuemei, Troncoso, Patricia, Titus, Mark, Broom, Bradley, Kim, Jeri, Corn, Paul G., Logothetis, Christopher J., Thompson, Timothy C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216801/
https://ncbi.nlm.nih.gov/pubmed/27331874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10113
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