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NF-Y loss triggers p53 stabilization and apoptosis in HPV18-positive cells by affecting E6 transcription

The expression of the high risk HPV18 E6 and E7 oncogenic proteins induces the transformation of epithelial cells, through the disruption of p53 and Rb function. The binding of cellular transcription factors to cis-regulatory elements in the viral Upstream Regulatory Region (URR) stimulates E6/E7 tr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Benatti, Paolo, Basile, Valentina, Dolfini, Diletta, Belluti, Silvia, Tomei, Margherita, Imbriano, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216769/
https://ncbi.nlm.nih.gov/pubmed/27323853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9974
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