Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells

Topoisomerases-IIα (TOP2A) enzyme is essential for cell viability due to its fundamental role in DNA metabolism and in chromatin organization during interphase and mitosis. TOP2A expression is finely regulated at the transcriptional level through the binding of the CCAAT-transcription factor NF-Y to...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Belluti, S, Basile, V, Benatti, P, Ferrari, E, Marverti, G, Imbriano, C
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763449/
https://ncbi.nlm.nih.gov/pubmed/23928695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.287
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