Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-IIα by bis-DemethoxyCurcumin in cancer cells

Topoisomerases-IIα (TOP2A) enzyme is essential for cell viability due to its fundamental role in DNA metabolism and in chromatin organization during interphase and mitosis. TOP2A expression is finely regulated at the transcriptional level through the binding of the CCAAT-transcription factor NF-Y to...

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Bibliografiske detaljer
Main Authors: Belluti, S, Basile, V, Benatti, P, Ferrari, E, Marverti, G, Imbriano, C
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763449/
https://ncbi.nlm.nih.gov/pubmed/23928695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.287
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