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Altered calcium influx of peripheral Th2 cells in pediatric Crohn's disease: infliximab may normalize activation patterns

OBJECTIVE: Crohn's disease is a chronic inflammation of the gastrointestinal tract with an abnormal immune phenotype. We investigated how intracellular calcium kinetics of Th1 and Th2 lymphocytes alter upon specific inhibition of Kv1.3 and IKCa1 channels in pediatric Crohn's disease. STUDY...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Orbán, Csaba, Szabó, Dolóresz, Bajnok, Anna, Vásárhelyi, Barna, Tulassay, Tivadar, Arató, András, Veres, Gábor, Toldi, Gergely
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216698/
https://ncbi.nlm.nih.gov/pubmed/27329601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10036
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