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Mechanistic Evaluation of Benzo[a]pyrene’s Developmental Toxicities Mediated by Reduced Cyp19a1b Activity
Benzo[a]pyrene (BaP) is a ubiquitous environmental contaminant that is both an endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis that is responsible for conversion of androgens to estrogens and thus plays a key role in steroid homeostasis. We hypothesized tha...
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| Опубликовано в: : | Toxicol Sci |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5216649/ https://ncbi.nlm.nih.gov/pubmed/27633980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw182 |
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