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A general role of the DNA glycosylase Nth1 in the abasic sites cleavage step of base excision repair in Schizosaccharomyces pombe

One of the most frequent lesions formed in cellular DNA are abasic (apurinic/apyrimidinic, AP) sites that are both cytotoxic and mutagenic, and must be removed efficiently to maintain genetic stability. It is generally believed that the repair of AP sites is initiated by the AP endonucleases; howeve...

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Bibliographic Details
Main Authors: Alseth, Ingrun, Korvald, Hanne, Osman, Fekret, Seeberg, Erling, Bjørås, Magnar
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC521664/
https://ncbi.nlm.nih.gov/pubmed/15452279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh851
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