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Adjust quality scores from alignment and improve sequencing accuracy
In shotgun sequencing, statistical reconstruction of a consensus from alignment requires a model of measurement error. Churchill and Waterman proposed one such model and an expectation–maximization (EM) algorithm to estimate sequencing error rates for each assembly matrix. Ewing and Green defined Ph...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521663/ https://ncbi.nlm.nih.gov/pubmed/15459287 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh850 |
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