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Adjust quality scores from alignment and improve sequencing accuracy

In shotgun sequencing, statistical reconstruction of a consensus from alignment requires a model of measurement error. Churchill and Waterman proposed one such model and an expectation–maximization (EM) algorithm to estimate sequencing error rates for each assembly matrix. Ewing and Green defined Ph...

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Bibliografische gegevens
Hoofdauteurs: Li, Ming, Nordborg, Magnus, Li, Lei M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2004
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC521663/
https://ncbi.nlm.nih.gov/pubmed/15459287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh850
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